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Journal Article 2

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2022 1

2020 1

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Biorational discovery 1

Herbicide 1

Mode of action 1

Natural products 1

herbicide / HPPD / inhibitor / quinoxaline / triketon 1

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Discovery for New Herbicide Sites of Action by Quantification of plant Primary Metabolite and Enzyme Perspective

Franck E. Dayan, Stephen O. Duke

Engineering 2020, Volume 6, Issue 5,   Pages 509-514 doi: 10.1016/j.eng.2020.03.004

Abstract:

No herbicide with a new molecular site of action (SOA) has been introduced since the 1980s.Two untried strategies for the discovery on new herbicide SOAs are discussed.Targeting SOAs that result in accumulation of phytotoxic compounds is the first novel approach to herbicideWe know that higher numbers of enzyme molecules for a SOA requires more herbicide to kill a plant.Modern proteomic methods can identify low enzyme level SOAs for biorational herbicide discovery.

Keywords: Natural products     Biorational discovery     Mode of action     Herbicide    

DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 133-145 doi: 10.15302/J-FASE-2021401

Abstract: HPPD has proved to be a promising target in herbicide research and development.

Keywords: herbicide / HPPD / inhibitor / quinoxaline / triketon    

Title Author Date Type Operation

Discovery for New Herbicide Sites of Action by Quantification of plant Primary Metabolite and Enzyme

Franck E. Dayan, Stephen O. Duke

Journal Article

DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN

Journal Article